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Publications - Project 2

Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus
Calsbeek JJ, Gonzalez EA, Boosalis CA, Zolkowska D, Bruun DA, Rowland DJ, Saito NH, Harvey DJ, Chaudhari AJ, Rogawski MA, Garbow JR, Lein PJ
NeuroToxicology. 2021 Aug 31; 87:43-50. PMID: 34478772

Perampanel, a potent AMPA receptor antagonist, protects against tetramethylenedisulfotetramine-induced seizures and lethality in mice: comparison with diazepam
Zolkowska D, Dhir A, Rogawski
Arch Toxicol. 2021 Jul;95(7):2459-2468. PMID: 33914090

Intranasal allopregnanolone confers rapid seizure protection: Evidence for direct nose-to-brain delivery
Zolkowska D, Wu CY, Rogawski MA
Neurotherapeutics. 2021 Jan;18(1):544-555. PMCID: PMC8116426

Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats
Dhir A, Bruun DA, Guignet M, Tsai Y-H, González E, Calsbeek J, Vu J, Saito N, Tancredi DJ, Harvey DJ, Lein PJ, Rogawski MA
Ann NY Acad Sci 2020 Sep 11, 1-23. PMCID: PMC7756871

The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity
González EA, Rindy AC, Guignet MA, Calsbeek JJ, Bruun DA, Dhir A, Andrew P, Saito N, Rowland DJ, Harvey DJ, Rogawski MA, Lein PJ .
Archives In Toxicolology 2020 June;94:2149-2162. PMCID: PMC7305973 (available on 2021-06-01)

National Institutes of Neurological Disorders and Stroke (NINDS)/American Epilepsy Society (AES) epilepsy research benchmark stewards. Epilepsy benchmarks area III: Improved treatment options for controlling seizures and epilepsy-related conditions without side effects
Traynelis SF, Dlugos D, Henshall D, Mefford HC, Rogawski MA, Staley KJ, Dacks  PA, Whittemore V, Poduri A
Epilepsy Curr. 2020 Jan-Feb;20(1_suppl):23S-30S. PMCID: PMC7031805.

Persistent behavioral deficits, neuroinflammation and oxidative stress in a rat model of acute organophosphate intoxication
Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ
Neurobiol Dis. 2020 Jan;133:104431. PMID: 30905768; PMCID: PMC6754818

Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus
Zolkowska D, Wu CY, Rogawski MA.
Epilepsia. 2018 October;59 Suppl 2:220-227. PMID: 29453777; PubMed Central PMCID: PMC6910080

Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats
Dhir A, Rogawski MA
Epilepsia.2018 May;59(5):935-944. PMID: 29682729; PMCID: PMC5934328

Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents
Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ
Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. PMID: 27467073 

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms
Zolkowska D, Dhir A, Krishnan K, Covey DF, Rogawski MA
Psychopharmacology (Berl). 2014 Sep;231(17):3325-32. PMID: 24705905 

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons
Chen CY, Matt L, Hell JW, Rogawski MA
PLoS One. 2014 Sep 17;9(9):e108021. PMID: 25229608 

Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis
Fritsch B, Reis J, Gasior M, Kaminski RM, Rogawski MA
J Neurosci. 2014 Apr 23;34(17):5765-75. PMID: 24760837 

Neuroactive steroids for the treatment of status epilepticus
Rogawski MA, Loya CM, Reddy K, Zolkowska D, Lossin C
Epilepsia. 2013 Sep;54 Suppl 6:93-8. PMID: 24001085

AMPA receptors as a molecular target in epilepsy therapy
Rogawski MA
Acta Neurol Scand Suppl. 2013;(197):9-18. PMID: 23480151 

Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine
Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA
J Pharmacol Exp Ther. 2012 May;341(2):435-46. PMID: 22328574