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Publications - Project 1

Structure-activity relationship of neuroactive steroids, midazolam, and perampanel towards mitigating tetramine-triggered activity in murine hippocampal neuronal networks
Antrobus S, Pressly B, Nik AM, Wulff H, Pessah IN
Toxicol Sci. 2021 Apr 12;180(2):325-341. PMID: 33483729

Rapid Throughput Analysis of GABAA Receptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye
Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Michael A. Rogawski MA, Wulff H, Pessah IN
Molecular Pharmacology April 20, 2017

Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents
Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ
Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. PMID: 27467073

Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture
Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN
Mol Pharmacol. 2015 Apr;87(4):595-605. PMID: 25583085

The riluzole derivative 2-Amino-6-trifluoromethylthiobenzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant
Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H
Neurotherapeutics. 2015 Jan;12(1):234-249. PMID: 25256961

Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity
Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN
Mol Pharmacol. 2014 Apr;85(4):630-9. PMID: 24482397;  PMCID:  PMC3965893

Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation
Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN
Toxicol Sci. 2012 Dec;130(2):362-72. PubMed PMID: 22889812; PMCID: PMC3529644