Publications - Core C
Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats
González EA, Calsbeek JJ, Tsai Y-H, Tang M-Y, Andrew P, Vu J, Berg EL, Saito NH, Harvey DJ, Supasai S, Gurkoff GG, Silverman JL, Lein PJ
Current Research in Toxicology. 2021. 2:341-356. In publication.
Persistent neuropathology and behavioral deficits in a mouse model of status epilepticus induced by acute intoxication with diisopropylfluorophosphate
Calsbeek JJ, González EA, Bruun DA, Guignet MA, Copping N, Dawson ME, Yu AJ, MacMahon JA, Saito NH, Harvey DJ, Silverman JL, Lein PJ.
Neurotoxicology. 2021 Sep 9:S0161-813X(21)00113-3. PMID: 34509511
Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus
Calsbeek JJ, Gonzalez EA, Boosalis CA, Zolkowska D, Bruun DA, Rowland DJ, Saito NH, Harvey DJ, Chaudhari AJ, Rogawski MA, Garbow JR, Lein PJ
NeuroToxicology. 2021 Aug 31; 87:43-50. PMID: 34478772
Letter to Editor: Requiring post-hoc power of 80% amounts to an unstated lowering of the type-1 error rate
Tancredi DJ, Harvey DJ, Smiley-Jewell S, Nguyen DV.
Neurotoxicology. 2021 Jan;82:99. PMID: 33232746
Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate.
Supasai S, González EA, Rowland DJ, Hobson B, Bruun DA, Guignet MA, Soares S, Singh V, Wulff H, Saito N, Harvey DJ, Lein PJ.
Eur J Pharmacol. 2020 Nov 5;886:173538. PMID: 32898549; PMCID: PMC7572820 (available on 2021-11-05)
Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats
Dhir A, Bruun DA, Guignet M, Tsai Y-H, González E, Calsbeek J, Vu J, Saito N, Tancredi DJ, Harvey DJ, Lein PJ, Rogawski MA
Ann NY Acad Sci 2020 Sep 11, 1-23. PMID: 32915470; PMCID: PMC7756871
The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity
González EA, Rindy AC, Guignet MA, Calsbeek JJ, Bruun DA, Dhir A, Andrew P, Saito N, Rowland DJ, Harvey DJ, Rogawski MA, Lein PJ .
Archives In Toxicolology 2020 June;94:2149-2162. PMID: 32303805; PMCID: PMC7305973 (available on 2021-06-01)
Persistent behavioral deficits, neuroinflammation and oxidative stress in a rat model of acute organophosphate intoxication
Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ
Neurobiol Dis. 2020 Jan;133:104431. PMID: 30905768; PMCID: PMC6754818
Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain
Bruce M, Streifel KM, Boosalis CA, Heuer L, González EA, Li S, Harvey DJ, Lein PJ, Van de Water J
J Neuroinflammation. 2019 Oct 31;16(1):200. PMID: 31672161; PMCID: PMC6822372.
Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication
Bruun DA, Guignet M, Harvey DJ, Lein PJ
Neurotoxicology. 2019 Jul;73:81-84 PMID: 30853371; PMCID: PMC66344995
A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication
Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR
Neurotoxicology. 2018 May;66:170-178. PMID: 29183789; PMCID: PMC5940565
Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate
Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ
Toxicol Sci. 2017 Jun 1;157(2):330-341. PMID: 28329845
From the Cover: Magnetic Resonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate
Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ
Toxicol Sci. 2017 Jun 1;157(2):342-353. PMID: 28329842
Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication
Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ
J Neuroinflammation. 2016 Oct 12;13(1):267.PMID: 27733171
Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures
Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ
Neuropharmacology. 2015 Aug;95:332-42. PMID: 25882826
Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior
Levoe SN, Flannery BM, Brignolo L, Imai DM, Koehne A, Austin AT, Bruun DA, Tancredi DJ, Lein PJ
Curr Neurobiol. 2014 Dec 1;5(1-2):1-10. PMID: 25705100
Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication
Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ
Toxicol Appl Pharmacol. 2014 Dec 1;281(2):185-94.PMID: 25448683