Publications - Core A

Publications - Core A

Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets
Yang J, Bruun DA, Wang C, Wan D, McReynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD
Toxicol Appl Pharmacol. 2019 Nov 1;382:114749. doi: 10.1016/j.taap.2019.114749. Epub 2019 Sep 12. PMID: 31521729

Sensitive immunoassay for detection and quantification of the neurotoxin, tetramethylenedisulfotetramine
Vasylieva N, Barnych B, Rand A, Inceoglu B, Gee SJ, Hammock BD
Analytical chemistry. 2017 May 16;89(10):5612-5619.
PubMed PMID: 28398746; PubMed Central PMCID: PMC5920647.

Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents
Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ
Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28. Review.
PMID: 27467073 [PubMed - indexed for MEDLINE]

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures
Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ
Neuropharmacology. 2015 Aug;95:332-42. doi: 10.1016/j.neuropharm.2015.03.035. Epub 2015 Apr 14. PMID: 25882826

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine
Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ
Neurotoxicol Teratol. 2015 Jan-Feb;47:36-45. doi: 10.1016/j.ntt.2014.10.008. Epub 2014 Nov 8.
PMID: 25446016 [PubMed - indexed for MEDLINE]

Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication
Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ
Toxicol Appl Pharmacol. 2014 Dec 1;281(2):185-94. doi: 10.1016/j.taap.2014.10.001. Epub 2014 Oct 14.
PMID: 25448683 [PubMed - indexed for MEDLINE]

GABAA receptor target of tetramethylenedisulfotetramine
Zhao C, Hwang SH, Buchholz BA, Carpenter TS, Lightstone FC, Yang J, Hammock BD, Casida JE
Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8607-12. doi: 10.1073/pnas.1407379111. Epub 2014 May 27. Erratum in:\
Proc Natl Acad Sci U S A.2014 Jul 29;111(30):11223. Lightstone, Felice [corrected to Lightstone, Felice C].
PMID: 24912155 [PubMed - indexed for MEDLINE]

Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures
Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD
PLoS One. 2013 Dec 11;8(12):e80922. doi: 10.1371/journal.pone.0080922. eCollection 2013.
PMID: 24349022 [PubMed - indexed for MEDLINE]

Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation
Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN
Toxicol Sci. 2012 Dec;130(2):362-72. doi: 10.1093/toxsci/kfs244. Epub 2012 Aug 13.
PMID: 22889812 [PubMed - indexed for MEDLINE]