Core A: Analytical Chemistry
Core A, or Analytical Chemistry, provides assistance to the three projects as well as Core B (Probe and Pharmaceutical Chemistry) by offering analytical support, training, and cutting-edge analytical techniques for drug and biomarker detection. Core A develops methods for the detection of the target compounds and their metabolites by using LC-MS (liquid chromatography-mass spectrometry) and GC-MS (gas chromatography-mass spectrometry).
Core B: Probe and Pharmaceutical Optimization
The role of Core B, the Probe and Pharmaceutical Optimization Core, is to promote the overall Center goal by providing general medicinal chemistry, formulation and pharmacology support. Core B will function as an integral component of the Center by supporting Projects 1, 2 and 3, and by closely collaborating with Core A, the Analytical Chemistry Core. Core B will synthesize the chemical threat agent tetramethylenedisulfotetramine (TETS) and specific mechanistic probes for the individual projects, including TETS-haptens and analogs for the development of a TETS detection assay in Core A.
Core C: Statistics and Data Management
The objective of the Statistics and Data Management (SDM) Core is to provide integrated support in statistics and database applications. The SDM core also coordinates with the Training and Education core to advise on statistical training for students as needed.
The overall objective of the Administrative Core is to oversee and coordinate the scientific and administrative operations of the Center’s activities and foster interactions and synergism among Center research projects and scientific cores, with the ultimate goal of ensuring that the Center meets the annual milestones established in collaboration with NIH CounterACT program officer(s). Additionally, the Administrative Core will coordinate interactions with external organizations such as the NIH CounterACT administration, our External Advisory Board and the general CounterACT research community.