Core A: Analytical Chemistry

Core A, or Analytical Chemistry, provides assistance to the three projects as well as Core B (Probe and Pharmaceutical Chemistry) by offering analytical support, training, and cutting-edge analytical techniques for drug and biomarker detection. Core A develops methods for the detection of the target compounds and their metabolites by using LC-MS (liquid chromatography-mass spectrometry) and GC-MS (gas chromatography-mass spectrometry). Core A also conducts quality control assessments, provides support in metabolomics, assists in ADME (absorption, distribution, metabolism, and excretion) studies and provides training for new scientists in modern analytical techniques.

Analytical Chemistry is responsible not only for service but also for the development of new analytical techniques and technologies that can serve both UC Davis CounterAct investigators and external CounterAct investigators.  Analytical Chemistry develops many components of toxin and therapy analysis to discover biomarkers of exposure and effect. The metabolomics evaluation conducted in Core A will assist in determining the effectiveness of the therapeutic strategies as well as providing a better understanding of drug-drug interactions. 

Related Publications

Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD
PLoS One 11;8(12):e80922. doi: 10.1371/journal.pone.0080922
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Vito ST, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, McCoy MR, Rogawski MA, Hammock BD, Lein PJ
Toxicol Appl Pharmacol (in press)
Hwang SH1, Wecksler AT, Wagner K, Hammock BD
Curr Med Chem. 2013;20(13):1783-99.
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Lee JY1, Kim YA, Kim MY, Lee YT, Hammock BD, Lee HS
Anal Chim Acta. 2012 Dec 13;757:69-74. doi: 10.1016/j.aca.2012.10.052. Epub 2012 Nov 6.
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Zolkowska D1, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA
J Pharmacol Exp Ther. 2012 May;341(2):435-46. doi: 10.1124/jpet.111.190579. Epub 2012 Feb 10.
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